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Retrieved 2016-03-02

Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis

Methyl / Thiol insufficiency In theory, there are many ways in which a burst of electron transfer reactions can impede apical exocytosis in acinar cells (21), but the evidence in patients with chronic pancreatitis points to a breakdown in the delivery of CH 3 and SH moieties (Figure 2) (21, 23-25)